The Medical University of South Carolina (MUSC) Facilities Master Plan is the culmination of many ideas generated through a rigorous planning process. This plan greatly expands on the pedestrian-focused greenway improvements by offering more green space and better connecting the campus through improved streetscapes. This master plan effort builds on the MUSC’s Strategic Plan: Imagine 2020. Through the construction of and reinvestment in some buildings, and the divestment of others, MUSC can better integrate its tripartite mission by creating physical connections between buildings and modern, interdisciplinary, innovative, and collaborative environments. The master plan also helps MUSC improve patient experience and establish a culture of health and wellness.