The master plan for University of Southern California’s 79-acre health sciences campus establishes a framework for guiding physical development over the next 25 to 30 years. It aims to reflect the high quality and reputation of the university’s programs through an upgraded physical setting. The plan was developed from a comprehensive analysis of the existing campus that involved the active participation of a diverse range of stakeholders. This process identified goals for the campus focused on the student and patient experience, as well as improvements to the built environment, including fitness, food, housing, hotel, and conference facilities for the many people who visit and work on the campus. The plan allows for the incremental physical growth of the campus in an economically feasible and sustainable manner.